ART-BMC

ART BMC™

1What is the ART BMC™?
The ART BMC™ concentration system recovers a high percentage of nucleated, progenitor and other cells by allowing selection of the cell concentrate from user-defined portions of the centrifuged stack. This miniaturized laboratory is designed as a single use sterile device that delivers a safe handling of cells.
2Features
  • Functionally closed system to minimize sterile breaks
  • Variable processing volume supports a variety of applications
  • Thumbwheel allows for selective deconstruction of fluid stack for personalized fluid products
  • Adjustable flow valve diverts fluid without additional sterile breaks
3Benefits
  • Efficient concentration yields ultra-low hematocrit
  • Adjustable white blood cell concentration for leukocyte-depleted product
  • Unmatched concentration of molecules, including fibrinogen, myoglobin, and cytokines of similar molecular weights4
  • Customized fluid fractions for tailored final product (e.g. BMC, fi brinogen, etc.)
  • Eliminates turbulence by keeping buffy coat in the collection zone
  • Consistently achieves high yields of mononuclear cells
4What Proteins, Growth Factors, and Molecules are Present in GFC?
• VEGF⁵
○New blood vessel growth
○Endothelial cell migration and proliferation

• PDGF⁵
○New blood vessel growth
○MSC recruitment and proliferation
○Helps form bone
○Increases collagen synthesis

• TGF-Beta⁵
○MSC proliferation
○Bone matrix deposition

• FGF⁵
○MSC proliferation
○Wound healing

• Alpha 2-Macroglobulin(A2M)⁶
○Prevents cartilage degeneration

• IRAP³
○Interleukin-1 receptor antagonist protein
○High levels in bone marrow
○Decreases inflammation

• FIBRINOGEN⁵
○Critcal for clot formation