ART BMC
ART BMC™
1What is the ART BMC™?
The ART BMC™ concentration system recovers a high percentage of nucleated, progenitor and other cells by allowing selection of the cell concentrate from user-defined portions of the centrifuged stack. This miniaturized laboratory is designed as a single use sterile device that delivers a safe handling of cells.
2Features
- Functionally closed system to minimize sterile breaks
- Variable processing volume supports a variety of applications
- Thumbwheel allows for selective deconstruction of fluid stack for personalized fluid products
- Adjustable flow valve diverts fluid without additional sterile breaks
3Benefits
- Efficient concentration yields ultra-low hematocrit
- Adjustable white blood cell concentration for leukocyte-depleted product
- Unmatched concentration of molecules, including fibrinogen, myoglobin, and cytokines of similar molecular weights4
- Customized fluid fractions for tailored final product (e.g. BMC, fi brinogen, etc.)
- Eliminates turbulence by keeping buffy coat in the collection zone
- Consistently achieves high yields of mononuclear cells
4What Proteins, Growth Factors, and Molecules are Present in GFC?
• VEGF⁵
○New blood vessel growth
○Endothelial cell migration and proliferation
• PDGF⁵
○New blood vessel growth
○MSC recruitment and proliferation
○Helps form bone
○Increases collagen synthesis
• TGF-Beta⁵
○MSC proliferation
○Bone matrix deposition
• FGF⁵
○MSC proliferation
○Wound healing
• Alpha 2-Macroglobulin(A2M)⁶
○Prevents cartilage degeneration
• IRAP³
○Interleukin-1 receptor antagonist protein
○High levels in bone marrow
○Decreases inflammation
• FIBRINOGEN⁵
○Critcal for clot formation
○New blood vessel growth
○Endothelial cell migration and proliferation
• PDGF⁵
○New blood vessel growth
○MSC recruitment and proliferation
○Helps form bone
○Increases collagen synthesis
• TGF-Beta⁵
○MSC proliferation
○Bone matrix deposition
• FGF⁵
○MSC proliferation
○Wound healing
• Alpha 2-Macroglobulin(A2M)⁶
○Prevents cartilage degeneration
• IRAP³
○Interleukin-1 receptor antagonist protein
○High levels in bone marrow
○Decreases inflammation
• FIBRINOGEN⁵
○Critcal for clot formation