ART-BMC-Plus

ART BMC™ PLUS

1What is the ART BMC™ PLUS?
The ART BMC™ PLUS concentration system features an integrated filter system for the ultrafiltration of proteins from platelet-poor plasma. By pushing the plasma from one syringe through the hundreds of hollow, nanoporous fibers, water and salt ions are pushed out while proteins and cells are further concentrated. The fluid may be concentrated by passing through the filter until the desired volume is obtained. This ultrafiltration enriches the concentration of most proteins like VEGF, PDG-F, TGF-Beta, FGF, Alpha-2 Macroglobulin, Interleukin-1 receptor antagonist protein, and Fibrinogen.1, 2, 3
2Features
  • ART BMC™ PLUS features integrated fibers for plasma concentrate
  • Functionally closed system to minimize sterile breaks
  • Variable processing volume supports a variety of applications
  • Thumbwheel allows for selective deconstruction of fluid stack for personalized fluid products
  • Adjustable flow valve diverts fluid without additional sterile breaks
3Benefits
  • Efficient concentration yields ultra-low hematocrit
  • Adjustable white blood cell concentration for leukocyte-depleted product
  • Unmatched concentration of molecules, including fibrinogen, myoglobin, and cytokines of similar molecular weights4
  • Customized fluid fractions for tailored final product (e.g. BMC, fi brinogen, etc.)
  • Eliminates turbulence by keeping buffy coat in the collection zone
  • Consistently achieves high yields of mononuclear cells
4What Proteins, Growth Factors, and Molecules are Present in GFC?
• VEGF⁵
○New blood vessel growth
○Endothelial cell migration and proliferation

• PDGF⁵
○New blood vessel growth
○MSC recruitment and proliferation
○Helps form bone
○Increases collagen synthesis

• TGF-Beta⁵
○MSC proliferation
○Bone matrix deposition

• FGF⁵
○MSC proliferation
○Wound healing

• Alpha 2-Macroglobulin(A2M)⁶
○Prevents cartilage degeneration

• IRAP³
○Interleukin-1 receptor antagonist protein
○High levels in bone marrow
○Decreases inflammation

• FIBRINOGEN⁵
○Critcal for clot formation
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